今天我们做一次标题党,所谓“大力神丸”就是通常的万艾可。
一位年轻小伙子主诉2月前服用一次泰国版西地那非后出现双眼视物模糊来诊。
什么,我一下子就联想到了西地那非导致的AION。此前我们也报道过不少服用“壮阳药”后出现AION患者,但多为中老年男性,难道这位年轻人有明显的解剖学拥挤视盘?
然而患者双眼视盘边界非常清晰,不符合AION的诊断,而且绝非高危视盘!
患者眼底双侧视盘边界清晰,并非高危视盘
所以,定位于视网膜,很快其他检查结果出炉。
视野散在暗点,也并非AION
细心观察OCT发现些许端倪,双眼黄斑上缘的外核层似乎存在小片高反射病灶(红圈),由此我们联想到一种好发于年轻近视人群的疾病——急性黄斑神经视网膜病变(Acutemacularneuroretinopathy,AMN)。
AMN也是AZOOR家族一员,病因目前倾向由黄斑区视网膜深层血管网缺血造成。由于发病时间过长,错过了急性期,我们煞费苦心也只是发现精准多焦ERG找到黄斑中心区功能障碍的证据。
想当年辉瑞公司为了明确他们的蓝精灵和NAION发病是否有关而斥巨资发起的临床对照试验,虽然证明了自己的清白,但也是花费了不少费用的!
说回到我们患者所服用的药物,google了一下小袋子上Kamagra,发现原来竟然是印度产神药,并非FDA通过的万艾可(西地那非),而是非法药物!!!
所以,这锅西地那非应该不用背,甚至文献中报道的那例视网膜病变也是用了网购药物。不知道这里面是否还掺杂了其他成分?小伙子很爽气地给我留了一包药,看看群里面哪位大神可以帮助测测成分啊!
最终诊断:双眼AMN。
Takehomemessages
1.“西地那非”在眼部可诱发AION和AMN。2.外核层高反射病灶、EZ/IZ反射异常联合mfERG改变是判断AMN的重要依据。
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参考文献:
1.YanogaF,GentileRC,etal.Sildenafilcitrateinducedretinaltoxicity-electroretinogram,opticalcoherencetomography,andadaptiveopticsfindings.Retinalcasesbriefreports,
2.田国红.福祸相依——1例药物诱发的非动脉炎性前部缺血性视神经病变.中国眼耳鼻喉科杂志,,19(4):-.
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